cenobamate will improve the level or impact of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep an eye on Closely. Look at a dose reduction of CYP2C19 substrates, as clinically correct, when utilised concomitantly with cenobamate.
diazepam decreases levels of acetaminophen rectal by escalating metabolism. Insignificant/Importance Unidentified. Enhanced metabolism incr amounts of hepatotoxic metabolites.
Coadministration of encorafenib with sensitive CYP3A4 substrates might result in enhanced toxicity or decreased efficacy of these agents.
Lencapavir (a reasonable CYP3A4 inhibitor) may possibly increase CYP3A4 substrates initiated within just nine months after previous SC dose of lenacapavir, which may raise possible danger of adverse reactions of CYP3A4 substrates.
diazepam will increase the degree or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
hydrocortisone will lower the level or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Coadministration of encorafenib with delicate CYP3A4 substrates may lead to improved toxicity or diminished efficacy of such agents.
Energetic metabolites: N-desmethyldiazepam and temazepam, which are equally even more metabolized to oxazepam; mostly eradicated by glucuronidation
Unlock Improved capabilities & extensive drug insights, which include comprehensive conversation knowledge & regulatory standing. Produce a free account.
Concomitant utilization of benzodiazepines and opioids may end in profound sedation, respiratory depression, coma, and Demise
Efficacy and protection of parenteral diazepam has not been founded in neonate (thirty times or much less of age); extended central nervous process depression is noticed in neonates, seemingly because of lack of ability to biotransform diazepam into inactive metabolites; benzyl Liquor has been claimed to generally be related to a fatal gasping syndrome in untimely infants Not advised for Continual, daily use being an anticonvulsant as a result of prospective for progress of tolerance to diazepam; more info Continual everyday usage of diazepam may perhaps maximize frequency and/or severity of tonic-clonic seizures, demanding a rise in dosage of standard anticonvulsant medication; in these types of cases, abrupt withdrawal of Continual diazepam could also be connected to A short lived rise in the frequency and/or severity of seizures
diazepam will enhance the stage or outcome of flibanserin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Greater flibanserin adverse outcomes may possibly take place if coadministered with numerous weak CYP3A4 inhibitors.
nifedipine will enhance the stage or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
diazepam boosts toxicity of oliceridine by Other (see remark). Modify Therapy/Check Carefully. Remark: Anticholinergic prescription drugs may well boost risk of urinary retention and/or significant constipation, which can bring about paralytic ileus.